Tacrolimus IV Standardization
نویسندگان
چکیده
منابع مشابه
The need for standardization of tacrolimus assays.
BACKGROUND Owing to the lack of an internationally recognized tacrolimus reference material and reference method, current LC-MS and immunoassay test methods used to monitor tacrolimus concentrations in whole blood are not standardized. The aim of this study was to assess the need for tacrolimus assay standardization. METHODS We sent a blinded 40-member whole-blood tacrolimus proficiency panel...
متن کاملStandardization of LC-MS for therapeutic drug monitoring of tacrolimus.
BACKGROUND LC-MS is increasingly used for therapeutic drug monitoring of tacrolimus. A recent summary from an international proficiency-testing scheme demonstrated that the mass spectrometry respondents were the largest method group. However, these methods lack standardization, which may explain the relatively poor interlaboratory agreement for such methods. This study aimed to provide one path...
متن کاملTacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation
Calcineurin inhibitors remain an integral component of immunosuppressive therapy regimens following solid organ transplantation. Although nephrotoxicity associated with these agents is well documented, type IV renal tubular acidosis is a rare and potentially underreported complication following liver transplantation. Hepatologists must be able to recognize this adverse effect as it can lead to ...
متن کاملDipeptidyl Peptidase IV Inhibitor MK-0626 Attenuates Pancreatic Islet Injury in Tacrolimus-Induced Diabetic Rats
BACKGROUND Tacrolimus (TAC)-induced pancreatic islet injury is one of the important causes of new-onset diabetes in transplant recipients. This study was performed to evaluate whether a dipeptidyl peptidase IV (DPP IV) inhibitor is effective in improving TAC-induced diabetes mellitus by reducing pancreatic islet injury. METHODS Rats were treated with TAC (1.5 mg/kg, subcutaneously) and the DP...
متن کاملTacrolimus in renal transplantation.
The early studies with tacrolimus. from 1989 through 1991, included a pilot series, a small randomized trial, and a larger nonrandomized group. I.3.4 When the outcome of these patients was compared with that in a roughly concurrent (although somewhat less challenging) group of cyclosporine (CyA)-treated patients, equivalent patient and graft survival rates were seen. However, improved secondary...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2016
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2015.11.1044